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Nicotine absorbs through the skin and mucous membranes, so you must store and dispose of your NRT safely. Nicotine overdose can be fatal, but this is rare and requires taking in very high doses of nicotine. Overdose is more of a problem in children and pets because of their smaller size. Keep NRT and used gum, patches, empty cartridges, bottles, etc., safely away from children and pets. Never drop them on the street or in open trash cans where kids and animals can reach them.
NICORETTE QuickMist is clinically proven to be 2.5 times more effective at helping smokers quit than by willpower alone. The fine spray format is an effective way of replacing some of the nicotine your body is used to getting from cigarettes, allowing you to relieve your nicotine cravings wherever and whenever you feel them.
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The products are manufactured by McNeil Consumer Healthcare company, a subsidiary of Johnson & Johnson, in Helsingborg, Sweden and are sold globally by Johnson & Johnson, even in the Middle East, except for in the United States where Nicorette is distributed by Haleon.
The NICORETTE QuickMist is a disposable unit. They are easy to store and take with you wherever you go. The disposable nature of this quitting aid makes it convenient to have multiple units for the various parts of your life. That lets you keep one in your car, one at work, and one anywhere else, without worry. eBay has various sizes available, and each one can provide a specific number of sprays.
The principal finding that, compared to app reporting, questionnaire data may overreport adherence is based on the repeated observation of instances in which participants specifically reported not using NRT to the app on one or more days, but later reported to questionnaires that NRT was used on these days. Additionally, some participants appeared to report very high mean daily nicotine doses to the questionnaire but not to the app. It is plausible that app data may have underestimated NRT use, as we assumed that no NRT was used on days when no app report was made; however, we found clear examples where participants reported greater NRT use to questionnaires when app data were present for the same period. It is possible that, relative to the app, social desirability may have affected questionnaire data collection carried out by telephone (ie, in Cohorts 1 and 2), although when questionnaire data were collected by online survey in Cohort 3, the tendency to report having used NRT on all 28 days was still high. Hence, we think it probable that app data reported a maximum of 48 hours after NRT use were more accurate than questionnaire data recalled 7 or 28 days later, and the skew toward questionnaire reports of NRT use on all days in a recall period reflects this effect. Given the study design, there may be alternative explanations; however, as recall of events is probably better closer to their occurrence , we think that this is the most plausible explanation.
Daily reporting of NRT adherence via an app may have several potential advantages over retrospective reporting at study follow-ups. First, the accuracy of participant recall is likely to be better with shorter intervals since a behavior occurred; this is central to the EMA approach to data collection, which aims to minimize recall bias and maximize ecological validity . Without keeping records, participants may struggle to accurately recall the number of days on which they used NRT given longer time intervals. This seems to have occurred in this study as, for some participants, higher retrospectively reported NRT usage was explicitly contradicted by daily app reports of days when no NRT was used, particularly at Day 28. It is also possible that, with retrospective measures, participants are unclear about the exact period they are supposed to be reporting for, particularly if there is a delay in completion of measures. The precise amounts of fast-acting NRT used are likely to be even more difficult to recall or prone to error. Several large outliers were evident for the Day 7 questionnaire measure of NRT dosage relative to the app, and it is possible that these participants reported a weekly total rather than daily average. Consequently, daily adherence reporting may be preferential for measuring adherence to NRT in trials, which often have treatment periods of 4 weeks or more and where fast-acting NRT might be used, and an app provides an ideal tool for collecting daily measurements.
A second potential advantage is that app data are available to researchers as soon as they are submitted. This means that, with daily app reports, participants lost to follow-up may still provide useful adherence data right up until the point of dropout or withdrawal, whereas periodic or end-of-study measures can only be completed by participants retained in studies. In this study, more than half of participants with no questionnaire data had provided some app data, particularly within the first 7 days. This could permit better estimates of treatment adherence in trials and provide informative data on those who withdraw. 041b061a72